Abstract
This study was undertaken to determine the antioxidant and antimicrobial effect of essential oil and extracts of Echinophora sibthorpiana Guss. (fam. Apiaceae) collected in Macedonia. The chemical composition of E. sibthorpiana essential oil was characterized by the presence of methyl eugenol (60.40%), p-cymene (11.18%) and ?-phellandrene (10.23%). The free radical scavenging activity of extracts and essential oil was evaluated by DPPH and ABTS assays. The aqueous extract of aerial parts exhibited the strongest scavenging activity (IC50=1.67 mg/ml); results of the ABTS test showed that the most effective was the ethanol extract of aerial parts (1.11 mg vit. C/g). The essential oil showed stronger antioxidant activity compared to hydroxyanisole, ascorbic acid and quercetin that were used in the DPPH and ABTS tests, respectively. The total phenolic and flavonoid concentrations in the extracts ranged between 38.65-60.72 mg GA/g, and 3.15-19.00 mg Qu/g, respectively. The antimicrobial properties of the extracts and essential oil were investigated using a micro-well dilution technique against human pathogenic strains. The results were comparable with the effects of the positive controls, streptomycin and fluconazole. These findings indicate that E. sibthorpiana extracts and oil can be used in preventive treatments and as an alternative for synthetic preservatives.
Highlights
IntroductionApiaceae=Umbelliferae) is represented by two species (E. spinosa L. and E. tenuifolia L.), distributed from the Mediterranean region eastwards to Crete and Crimea
Our results showed that the oil contained 11.54% of phenylpropanoids, one oxygenated sesquiterpene and one diterpene (3.85% of each)
While several reports about the oil composition of this species have been published previously, no data have been published on the chemical composition of the essential oil from Macedonia
Summary
Apiaceae=Umbelliferae) is represented by two species (E. spinosa L. and E. tenuifolia L.), distributed from the Mediterranean region eastwards to Crete and Crimea. According to more recent literature data, later subspecies should be treated as separate species – Echinophora sibthorpiana Guss. Sibthorpiana is traditionally used in Turkey as an antispasmodic and digestive herb (Cakilcioglu and Turkoglu, 2010). Since ancient times the seeds and root of E. tenuifolia are efficient in the treatment of epilepsy (Eadie, 2004). Fresh or dried herbs are used as local fungicidal medicaments, KSENIJA MILESKI ET AL
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