Abstract
Radiation therapy, Liver metastases, Complications. One of the first clinical reports of a series of patients who underwent irradiation of the entire liver for metastatic carcinoma” indicated that there were no adverse hepatic effects of that radiation and inferred the relative radioresistence of that organ, in spite of earlier suggestions to the contrary.’ Coincident in time with this attitude was the medical application of megavoltage radiation equipment’ which provided the capability of delivering larger and more homogenous doses of radiation at a depth within patients. It was hoped, therefore, that tumor control in the face of metastatic liver disease might be possible by utilizing whole liver irradiation. Likewise, it was considered feasible to apply prophylactic whole abdominal irradiation, inclusive of the entire liver, either by the technique of multiple wide portals of irradiation or that of the moving-strip, to other patients who were at risk for the development of diffuse intra-abdominal carcinoma or lymphoma.’
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