Radiation Therapy (RT) Target Volume Definition for Peripheral Primitive Neuroectodermal Tumor (PPNET) by Use of Multimodality Imaging: An Original Article

Selcuk Demiral

doi:10.26717/bjstr.2021.34.005586

Abstract

Primitive neuroectodermal tumor (PNET) refers to a group of highly malignant tumors consisting of small round...

Highlights

Multimodality imaging with incorporation of magnetic resonance imaging (MRI) in the target definition process may be considered for improving the accuracy and precision despite the need for further supporting evidence
Primitive neuroectodermal tumor (PNET) refers to a group of highly malignant tumors consisting of small round cells of neuroectodermal origin which may affect both soft tissues and bones and these rare but aggressive variant of small round cell carcinomas typically arising from the neural crest cells may be subdivided into central or peripheral PNET (PPNET) types [1-5]
In the context of radiation oncology discipline, there have been substantial progress in recent years with tremendous advances by introduction of adaptive irradiation strategies and modernized treatment delivery techniques with incorporation of Intensity Modulated Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), Breathing Adapted Radiation Therapy (BART), Adaptive Radiation Therapy (ART), automatic segmentation methods, molecular imaging techniques and stereotactic irradiation strategies [6-41]. In this original research article, we evaluated radiation therapy (RT) target volume definition for PPNET by use of multimodality imaging

Summary

Introduction

Primitive neuroectodermal tumor (PNET) refers to a group of highly malignant tumors consisting of small round cells of neuroectodermal origin which may affect both soft tissues and bones and these rare but aggressive variant of small round cell carcinomas typically arising from the neural crest cells may be subdivided into central or peripheral PNET (PPNET) types [1-5]. No standardized guideline exists for management of PPNET partly due to the rarity of cases arising in different body sites, multimodal treatment may be utilized as in Ewing sarcoma family of tumors [1-5] Within this context, surgery, systemic treatments and radiation therapy (RT) may be included in combined modality management of PPNET to achieve improved therapeutic outcomes [1-5]. In the context of radiation oncology discipline, there have been substantial progress in recent years with tremendous advances by introduction of adaptive irradiation strategies and modernized treatment delivery techniques with incorporation of Intensity Modulated Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), Breathing Adapted Radiation Therapy (BART), Adaptive Radiation Therapy (ART), automatic segmentation methods, molecular imaging techniques and stereotactic irradiation strategies [6-41] In this original research article, we evaluated RT target volume definition for PPNET by use of multimodality imaging

Methods

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Discussion

Conclusion