Radiation Therapy Oncology Group (RTOG) 9408: A Secondary Analysis of the Risk of Death From Second Cancers Comparing Whole Pelvic (WP) Radiation Therapy (RT) to Prostate Only (PO) RT and Neoadjuvant Hormonal Therapy (NHT) + RT to RT Alone

Abstract

A post hoc analysis of the long-term results of RTOG 9413 suggested that the use of WP RT might be associated with an increased risk of death from second cancers (SCs), even though the incidence of SCs did not appear to be increased. There was also a trend for NHT to be associated with a lower risk of SCs compared to adjuvant hormonal therapy (AHT). This secondary analysis was performed to determine whether or not these findings could be confirmed by comparing patients (pts) treated with WP compared to PO RT with and without NHT on RTOG 9408.