Radiation Therapy for Malignant Pheochromocytoma: Two Case Report and Review of the Literature

Abstract

Pheochromocytomas are rare tumors that occur in approximately 0.1% of patients with hypertension. About 10-15% of pheochromocytomas presents with metastasis. Patients with malignant pheochromocytoma have a poor prognosis with an average 5-year survival of about 40%. Primary surgical resection is the treatment of choice whenever possible. External beam radiation may also be the alternative treatment modality for some situations. We reported two cases of malignant pheochromocytomas who received radiotherapy as postoperative adjuvant treatment and palliation. Relevant literatures are also reviewed.