Abstract
One of the important matters that must be determined in advance when performing BNCT treatment is the optimization of neutron irradiation time and dose. In this article, following the previous article (2.52 × 1012 n/cm2) (Case 1), double irradiation (5.04 × 1012 n/cm2) was further performed (Case 2) by verifying the radiation sensitivity performance of the artificial tumor tissue NHDF3D/BxPC3 and the possibility of evaluating the optimum neutron dose required for treatment was examined. As a result, although the radiation damage rate in the normal tissue NHDF3D and the tumor tissue BxPC3 increased in proportion to the irradiation dose due to heavy irradiation in Case 1 or more, the increase in the damage rate in the normal tissue exceeded the tumor tissue. Furthermore, the tumor/normal tissue damage ratio T/N ratio showed the maximum value in Case 1, and the dose ratio in Case 2 with a higher dose showed a tendency to decrease. From the above experimental facts, it was shown that irradiation dose optimization is possible to some extent by an evaluation method using an artificial tumor tissue.
Highlights
In the previous paper [1], the authors made a bilayer 3D artificial tumor tissue (BxPC3/NHDF3D) using human pancreatic cancer cell line BxPC3 and normal human dermal-derived fibroblast NHDF3D, and pharmacokinetic study for 10BPA-Boron Neutron Capture Therapy (BNCT) treatment [2]-[10] by neutron irradiation from reactor Went
In this article, following the previous article (2.52 × 1012 n/cm2) (Case 1), double irradiation (5.04 × 1012 n/cm2) was further performed (Case 2) by verifying the radiation sensitivity performance of the artificial tumor tissue NHDF3D/BxPC3 and the possibility of evaluating the optimum neutron dose required for treatment was examined
In this paper, we examined the applicability of the 3D artificial tumor tissue used in the previous paper [1] as a testing technique for optimizing the radiation dose at the time of BNCT treatment while verifying the sensitivity performance to radiation dose
Summary
In the previous paper [1], the authors made a bilayer 3D artificial tumor tissue (BxPC3/NHDF3D) using human pancreatic cancer cell line BxPC3 and normal human dermal-derived fibroblast NHDF3D, and pharmacokinetic study for 10BPA-BNCT treatment [2]-[10] by neutron irradiation from reactor Went. Optical observation of the irradiated tissue gave a T/N ratio of 3.19 at a neutron dose of 2.52 × 1012 n/cm, indicating the effectiveness of the BNCT pharmacokinetics test using 3D artificial tissue [11]-[16]. In this paper, we examined the applicability of the 3D artificial tumor tissue used in the previous paper [1] as a testing technique for optimizing the radiation dose at the time of BNCT treatment while verifying the sensitivity performance to radiation dose
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