Abstract
The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh bone marrow were studied using an in vitro cell culture technique. Based on the survival curves of CFU-F, the D0 values of 60Co, HTO and 252Cf were 124 ± 30, 92 ± 12 and 60 ± 11 rad, respectively. From the D0 values of 60Co gamma rays, the relative biological effectiveness (RBE) of HTO beta rays and 252Cf neutrons were calculated to be 1.3 and 2.1. However, due to the difference in the survival curves with or without initial shoulder, the RBEs of HTO and 252Cf were dependent on the range of radiation dose. Both RBEs became higher than 3 in the low dose range of radiation (under 100 rad).
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