Radiation phenotypes of chronic obstructive pulmonary disease in patients with type 2 diabetes mellitus

Abstract

The relevance of the work is due to the lack of systematic data on the features of lung damage in patients with chronic obstructive pulmonary disease (COPD) and type II diabetes mellitus (DM2).Aim: To identify the main radiation phenotypes of lung tissue damage in patients with chronic obstructive pulmonary disease and type II diabetes mellitus.Material and Methods. We conducted a one-stage observational study, with the analysis of clinical data, laboratory and instrumental studies (pulmonary function tests, computed tomography), in patients with chronic obstructive pulmonary disease in combination with type II diabetes mellitus (57 people).Results. In patients with a combination of COPD and type II diabetes mellitus, the predominance of predominantly bronchitic type of COPD over emphysematous was revealed, with the presence of statistically significant links between a number of patterns (the presence of air trapping, bronchiolitis) and laboratory results (the number of eosinophils in the blood, the number of leukocytes in the blood and sputum, the number of macrophages in sputum, levels of IL-33, TNF-α, CRP, IFN-γ/IL-4 ratio), which may reflect the influence of different pathogenetic aspects of inflammation on the formation of structural changes in the lung tissue).Conclusion. For patients with a combination of chronic obstructive pulmonary disease and type II diabetes mellitus, the presence of a bronchitic COPD phenotype with the absence of confluent and destructive forms of pulmonary emphysema is more characteristic. The wide prevalence of the bronchitic COPD phenotype in patients with concomitant type 2 diabetes mellitus may be due to predominant changes in the small airways, the development of microangiopathy, as well as an infectious factor, since patients with type 2 diabetes mellitus, in general, are more susceptible to infections, including respiratory.