Abstract

Radiotherapy of pelvic tumours results often in unavoidable side effects. One of these–radiation-induced urinary bladder dysfunction–occurs in three phases: an early, reversible reaction, a dose-dependent, symptom-free latent time, and a progressive and irreversible late response phase. Since the cellular mechanisms underlying these early and late effects are not fully understood, studies in experimental animals are needed. The present investigation addressed the question whether impairment of the urothelial barrier contributes to radiation effects in the mouse urinary bladder.

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