Abstract
Simple model systems were used to characterize the nature of radioinduced DNA strand breaks. Using DNA labeled with [$sup 3$H] thymidine, it was shown that three monomeric thymine-derived products are released from DNA by irradiation. All three increase with time after irradiation. It was concluded that two post-irradiation time-dependent processes occur in macromolecular DNA: the yield of actual strand breaks increases by a factor of 2; and the chemical nature of the strand break terminus changes, i.e., the yield of monomeric bases continues to increase after the strand break yield has reached a maximum. (HLW)
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