Abstract
Silicone rubber (SR) is a material used for medical procedures, with a common example of its application being in implants for cosmetic or plastic surgeries. It is also an essential component for the development of medical devices. SR was functionalized with the polymeric prodrug of poly(2-methacryloyloxy-benzoic acid) (poly(2MBA)) to render the analgesic anti-inflammatory drug salicylic acid by hydrolysis. The system was designed by functionalizing SR films (0.5 cm × 1 cm) with a direct grafting method, using gamma irradiation (60Co source) to induce the polymerization process. The absorbed dose (from 20 to 100 kGy) and the monomer concentration (between 0.4 and 1.5 M) were critical in controlling the surface and the bulk modifications of SR. Grafting poly(2MBA) onto SR (SR-g-2MBA) were characterized by attenuated total reflectance Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy/energy-dispersive X-ray spectrometry, fluorescence microscopy, the contact angle, and the swelling. SR-g-2MBA demonstrated the drug’s sustained and pH-dependent release in simulated physiological mediums (pH = 5.5 and 7.4). The drug’s release was quantified by high-performance liquid chromatography and confirmed by gas chromatography–mass spectrometry. Finally, cytocompatibility was demonstrated in murine fibroblast and human cervical cancer cell lines. The developed systems provide new polymeric drug release systems for medical silicone applications.
Highlights
Medical devices are essential to many surgical procedures [1]; it is important to have implantable devices that help reduce the inflammatory processes caused by tissue lesions or immunological responses, which have the consequence of prolonging a patient’s hospital stay [2,3].Polymers 2020, 12, 1297; doi:10.3390/polym12061297 www.mdpi.com/journal/polymersAnother negative effect related to these devices is bacterial or fungal infections either caused by poor sterilization of the device or acquired in hospitals [4,5,6]
The increasing increasing monomer monomer concentrations concentrations there experiment demonstrated a growth in the graft percentage in the intervals between
We evaluated the thermal stability of Silicone rubber (SR), poly(2MBA), and (SR-g-2MBA) (Figure 2A)
Summary
Medical devices are essential to many surgical procedures [1]; it is important to have implantable devices that help reduce the inflammatory processes caused by tissue lesions or immunological responses, which have the consequence of prolonging a patient’s hospital stay [2,3].Polymers 2020, 12, 1297; doi:10.3390/polym12061297 www.mdpi.com/journal/polymersAnother negative effect related to these devices is bacterial or fungal infections either caused by poor sterilization of the device or acquired in hospitals [4,5,6]. Medical devices are essential to many surgical procedures [1]; it is important to have implantable devices that help reduce the inflammatory processes caused by tissue lesions or immunological responses, which have the consequence of prolonging a patient’s hospital stay [2,3]. Another negative effect related to these devices is bacterial or fungal infections either caused by poor sterilization of the device or acquired in hospitals [4,5,6]. The materials used for medical devices include silicone, polypropylene, poly(vinyl chloride), and polyurethanes [9]. Controlled drug-release systems (anti-inflammatory, analgesic, or antimicrobial), incorporated or loaded in the silicone, are an attractive strategy for solving the problems associated with these types of medical procedures [10,11]
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