Abstract

Development of controlled drug release carriers with gastroretentive ability is one of the most feasible approaches to improve the bioavailability and efficiency of medical treatment of Helicobacter pylori-induced peptic ulcers. Consequently, modification of alginate with N, N-dimethylamino ethyl methacrylate was occurred via graft copolymerization technique using γ-irradiation. (Alg-g-DMAEMA) copolymers were used to prepare Amoxicillin-Trihydrate floated hollow beads using calcium chloride as crosslinker and calcium carbonate as a gas-forming agent to induce floatability. Swelling behavior, floatability, and gastric retention time were investigated in simulated gastric fluid. Morphological features, drug encapsulation efficiency, and in vitro (AT) release were evaluated. Beads show internal hollow construction with bulk density ranged from 0.393 to 1.533 (g/cm3) and enhanced gastric residence time extended up to 24 h. Drug entrapment efficiency ranged between 63 to 97% with sustainable release behavior extending beyond 15 h depends on beads p (DMAEMA) content. The newly developed pH-sensitive floated (AT) loaded (Alg-g-DMAEMA) beads are promising for increasing gastric residence time with sustained (AT) release which improves its bioavailability for the effective treatment of H. pylori. The in-vitro study showed that (AT) loaded beads eradicate more than 95% of H. pylori after 10 h.

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