Abstract
Purpose/Objective: Angiosarcomas are rare aggressive tumors of endothelial origin. They may arise sporadically or as a result of previous ionizing radiation exposure or chronic lymphedema, as first described by Stewart and Treves. Latency periods for the development of radiation-associated angiosarcoma (RAA) may be many years. It is unclear why some patients develop RAA after irradiation while others do not and the mechanisms of radiation-associated sarcogenesis remain unknown. In this report, we describe the clinical, pathologic, and treatment information on a series of RAA patients.
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