Abstract
In this study, we analyze stain growth kinetics from droplets of biological fluids such as blood, plasma, and protein solutions on paper both experimentally and numerically. The primary difference of biological fluids from a simple fluid is a significant wetting/dewetting hysteresis in paper. This becomes important in later stages of droplet wicking, after the droplet has been completely absorbed into paper. This is shown by anomalous power dependence of area with time in the later stages of radial wicking. At early stages, current numerical wicking models can predict stain growth of biological fluids. However, at later stages, the introduction of hysteresis complicates modeling significantly. We show that the cause of the observed hysteresis is due to contact angle effects and that this is the dominant mechanism that leads to the anomalous stain growth kinetics measured uniquely in biological fluids. Results presented will streamline the design process of paper-based diagnostics, allowing a modeling approach instead of a trial and error method.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.