Radial Artery Tonometry Demonstrates Arterial Stiffness in Children With Type 1 Diabetes

Michael J Haller,Todd Brusko,Gary L Pierce,Clive Wasserfall,R Fletcher Schwartz,Jonathan J Shuster,Janet H Silverstein,Margaret Samyn,Mark Atkinson,Wilmer W Nichols

doi:10.2337/diacare.27.12.2911

Michael J Haller, Todd Brusko + Show 8 more

Open Access

https://doi.org/10.2337/diacare.27.12.2911

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Journal: Diabetes care	Publication Date: Nov 23, 2004
Citations: 144	License type: cc-by

Affiliation: University of Florida

Abstract

To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry. We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10-18 years, matched for age, sex, race, and BMI, generating 43 matched pairs. Radial artery tonometry was performed, and blood was collected for analysis of fasting lipids, HbA1c, glucose, and cytokines in all children. Children with diabetes had a significantly higher augmentation index corrected to a heart rate of 75 (AI75) than their matched control subjects. Mean AI75 in type 1 diabetic subjects was 1.11 +/- 10.15 versus -3.32 +/- 10.36 in control subjects. The case-control difference was 5.20 +/- 11.02 (P=0.0031). Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes.

Highlights

RESEARCH DESIGN AND METHODS — We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10 –18 years, matched for age, sex, race, and BMI, generating 43 matched pairs
Children with diabetes had a significantly higher augmentation index corrected to a heart rate of 75 (AI75) than their matched control subjects
Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes

Summary

Introduction

RESEARCH DESIGN AND METHODS — We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10 –18 years, matched for age, sex, race, and BMI, generating 43 matched pairs. CONCLUSIONS — Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Recent studies have demonstrated that endothelial function, as measured by brachial reactivity and carotid intimamedial thickness (IMT), are abnormal in children with type 1 diabetes [5]; no one has yet demonstrated if radial tonometry can provide similar results.

Results

Conclusion