Abstract
Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.
Highlights
While it is important to raise the awareness of yeast researchers to the importance of RAD5 genotype in yeast, it is important to highlight how the mammalian Rad5 orthologs, such as helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH), play multiple important roles in mammalian cells
Upregulation of regenerating gene (REG) genes is beneficial on the one hand because it induces the proliferation of intestinal epithelial cells, protecting them from damage caused by the immune system, but on the other hand upregulation increases the risk of developing colon cancer [10]
We propose that developing inhibitors that prevent the interaction between HLTF and the REG1B promoter could be useful to reduce the expression of REG-1b after colon regeneration, and reduce the risk of colon cancer (Figure 1B)
Summary
Have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are involved in multiple biological functions and are associated with several human disorders. While it is important to raise the awareness of yeast researchers to the importance of RAD5 genotype in yeast, it is important to highlight how the mammalian Rad5 orthologs, such as HLTF and SHPRH, play multiple important roles in mammalian cells.
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