Abstract
Abstract Background Glioblastoma is one of the most aggressive brain malignancies in adults with limited data evaluating the racial disparities in incidence or mortality. In this study, we aim to study the temporal trends of incidence and mortality and assess ethnic impact on the outcomes. Methods We used the SEER database to study glioblastoma cases in the US during 1992-2015. Incidence and mortality rates of glioblastoma were calculated by race and were expressed in 100,000 person-years. Annual percent change (APC) was calculated using joinpoint regression software. Results We reviewed 27,905 glioblastoma patients, of which 1,518 were Asians, 1,471 were blacks, 127 were American Indians, and the others were whites. The incidence of glioblastoma was highest among whites (3.43) when compared to Asians (1.417), and blacks (1.724). Glioblastoma incidence among whites increased significantly over the study period (APC=0.51%, p-value Conclusion Asian patients have a lower incidence as well as mortality when compared to white or black patients. Understanding the environmental and genetic factors impacting the observed disparities may help alleviate the differences and improve overall patient outcomes.
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