Abstract
Levels of four urinary F2-isoprostanes (F2-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic Whites (NHWs), and 275 Hispanic Whites (HWs). F2-IsoP isomers – iPF2a-III, 2,3-dinor-iPF2a-III, iPF2a-VI, and 8,12-iso-iPF2a-VI – were measured in 854 urine samples using liquid chromatography with tandem mass spectrometry detection. In AAs, levels of all four F2-IsoPs were lower compared with NHWs and HWs (p-values < 0.05). When stratified by BMI, this gap was not observed among participants with normal BMI but appeared among overweight and increased among obese participants. Examining the slopes of the associations between BMI and F2-IsoPs showed no association between these variables among AAs (p-values > 0.2), and positive associations among Caucasians (p-values < 0.05). Taking into account that positive cross-sectional associations between systemic F2-IsoP levels and BMI have been consistently demonstrated in many study populations, the lack of such an association among AAs reveals a new facet of racial/ethnic differences in obesity-related risk profiles.
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