Abstract
<h3>To the Editor.</h3> —I read with great interest the article by Dr Eley and colleagues<sup>1</sup>regarding racial differences in survival from breast cancer. This investigation is one of the most complete, well-designed, and well-conducted studies to determine the nature of racial differences in breast cancer survival. The data-collection methods, management of confounding factors, and statistical analyses were exceptional. I have a question for the authors regarding frequency matching of white subjects to black subjects by age. By matching (overmatching) on this important variable, possible comparisons of age as a factor in survival were eliminated. Several studies<sup>2-4</sup>have indicated significantly younger age at diagnosis in African-American women compared with white women, along with poorer survival rates, which may indicate basic biological differences between tumors in these two groups. Age may be a major explanatory variable in survival differences between races, in addition to or instead of those found in
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