Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity

Abstract

Five new norneolignans sinkianlignans G-K (1–5), one phenolic compound ferulagenol A (6) and seven known compounds (7–13) were isolated from Ferula sinkiangensis. All the norneolignans were racemic mixtures, and chiral HPLC was used to further separate them. Their structures were assigned, including absolute configurations, using spectroscopic and computational methods. Biological evaluation showed that compounds 1–9 had significant COX-2 inhibitory activity with IC50 values ranging from 3.00 μM to 23.19 μM.