Abstract
Guanine nucleotide exchange factors (GEF) are proteins that regulate the activity of GTPases by catalysing the exchange of GDP for GTP. In this work, we studied the interaction of various Rho family GTPases CDC42, Rac1 and RhoA with GEFmeso, a GEF expressed in Drosophila melanogaster (fruit fly). The interaction of GEFmeso with Rho family GTPases was studied by means of guanine nucleotide exchange assays. Our results suggest that GEFmeso interacts with Rac1 in addition to its interaction with CDC42 and Ral, which was reported earlier. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
