Abstract
Rabies virus is an RNA virus in the Rhabdoviridae family that is transmitted in the saliva by an animal bite. Worldwide, dogs are the most important vector. Rabies is a fatal acute encephalomyelitis in humans and animals. Rabies has distinctive clinical features, including hydrophobia and about 20% of patients develop a paralytic form of the disease. Laboratory diagnosis includes the detection of neutralizing anti-rabies virus antibodies in the serum/cerebrospinal fluid and detection of rabies virus antigen and/or RNA in tissues (eg, skin) or fluids (eg, saliva). There is no effective therapy for rabies. Disease can be prevented after exposures with wound cleansing and administration of rabies vaccine and human rabies immune globulin.
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