Abstract
There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind rabies virus and/or facilitate rabies virus entry into cells. Other components of the cell membrane, such as gangliosides, may also participate in the entry of rabies virus. However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system.
Highlights
Infectious diseases of the nervous system: pathogenesis and worldwide impact Roberto Bruzzone, Monique Dubois-Dalcq, Georges E Grau, Diane E Griffin and Krister Kristensson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
The envelope G protein trimer is responsible for the attachment of the virus to target cells and enable the virus to be transported to the nervous system (NS) via the retrograde pathway
According to the localization of the three molecules, their role in entry and propagation of the virus could be as follows: Rabies virus (RABV) particles from saliva are transferred by bites to the vicinity of neuromuscular junction (NMJ) and sensory terminations
Summary
Infectious diseases of the nervous system: pathogenesis and worldwide impact Roberto Bruzzone, Monique Dubois-Dalcq, Georges E Grau, Diane E Griffin and Krister Kristensson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. . Address: Department of Virology, Institut Pasteur, 75015 Paris, France Email: Monique Lafon - mlafon@pasteur.fr from Infectious diseases of the nervous system: pathogenesis and worldwide impact Paris, France. Rabies virus (RABV) is a pathogen well adapted to the mammalian nervous system (NS) where it infects the neurons, causing an acute myelo-encephalitis fatal in most mammalian species, and humans in particular.
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