Abstract
Summary: Ten documented cases of rabies in dogs vaccinated with modified live virus (ML V) Flury-LEP vaccine in Anambra State of Nigeria between 1978 and 1985 are presented. The number constitutes 11% of laboratoryconfirmed canine rabies, and suggests a vaccination failure rate of 2.5 cases per 10,000 doses of vaccine administered during the period. The interval bet ween vaccination and clinical rabies ranged from six weeks to eleven months. Since the time and nature of exposure of the vaccinated dogs were unknown and the characteristics of the causative rabies viruses were not determined, it was not certain whether all ten cases represent immunity breaks or vaccineinduced rabies. All but one of the cases recorded involved human exposures. Probable causes and public health implications of immunity break and vaccine-induced rabies are discussed.
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