Abstract
In a malaria-endemic area of Africa, rabies was an important cause of fatal central nervous system infection, responsible for 14 (10.5%) of 133 cases. Four patients had unusual clinical manifestations, and rabies was only diagnosed postmortem. Three (11.5%) of 26 fatal cases were originally attributed to cerebral malaria.
Highlights
In a malaria-endemic area of Africa, rabies was an important cause of fatal central nervous system infection, responsible for 14 (10.5%) of 133 cases
As part of a prospective clinical study of viral central nervous system (CNS) infections and cerebral malaria in Malawian children, we investigated fatal cases for rabies virus
This study showed that rabies encephalitis is an important cause of death among children in Malawi
Summary
In a malaria-endemic area of Africa, rabies was an important cause of fatal central nervous system infection, responsible for 14 (10.5%) of 133 cases. As part of a prospective clinical study of viral central nervous system (CNS) infections and cerebral malaria in Malawian children, we investigated fatal cases for rabies virus. Rabies encephalitis was diagnosed in 10 children (1.3%) on the basis of history of exposure to a rabid animal and initial clinical manifestations (Table).
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