Abstract
A rabbit model for fentanyl-induced chest wall rigidity and the effect of apomorphine was evaluated. Eleven New Zealand adult rabbits were anesthetized and mechanically ventilated. An esophageal balloon catheter was used to estimate pleural pressure (Ppl). Chest wall compliance (Ccw) at baseline was calculated during pentobarbital anesthesia. A loading dose of 0.1mgkg−1 of fentanyl followed by infusion of 0.01mgkg−1min−1 was started in all animals, and Ccw reassessed. In the rabbits that developed decreased Ccw, apomorphine 0.4mgkg−1 followed by a 0.004mgkg−1min−1 was administered and Ccw was reassessed. Ccw at baseline and after fentanyl and fentanyl+apomorphine were compared with one-way ANOVA followed by Bonferroni–Holm test (P<0.05). In 5 rabbits, Ccw decreased significantly after fentanyl administration and apomorphine was able to restore Ccw to baseline values. Rabbits can be used as a model for fentanyl-induced chest wall rigidity. Results from this study support central dopaminergic pathways as being at least partially responsible for the opioid-induced chest wall rigidity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
