Abstract

Introduction: One of the main concerns in administration of radiotracers, especially in therapeutic arm, is the amount of delivered dose to the different organs. Individual variations of anatomy, physiology and underlying pathology in the patients lead to alteration of administered activity. In the current study we preclinically applied internal dosimetry using an animal model Materials and Methods: The SPECT/CT imaging of a rabbit 24 hours after administration of 288μci Iodine-131 was done. Biodistribution of radiotracer was obtained from SPECT, and the CT was used to define attenuation map and the target volume of interest (VOIs). Dosimetry calculations were performed with GATE Monte Carlo code and S-values for beta and gamma radiation of different organs were calculated. Results: The S-values of thyroid as target organ are 1.09×10-4(mGy/MBq/sec) for beta and 1.05×10- 5 for gamma radiation. And S-values of kidneys, lungs, spine, and heart as critical organs are 1.10×10-5, 1.58×10-5, 7.62×10-6, 6.75×10-6 for beta, respectively and 3.9×10-6, 2.69×10-6, 2.63×10-6, 3.27×10-6 for gamma, respectively Conclusion: The internal dosimetry is applicable clinically. The response to therapy would be increased and the side effect would be minimized if the prescription using patient specific dosimetry is optimized.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.