Abstract
Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab23 is also a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab23 has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visceral, and cutaneous tumor. In addition, Rab23 may play joint roles in autophagosome formation during anti-infection process against Group A streptococcus. In this review, we give a brief review on the functions of Rab23, summarize the involvement of Rab23 in genetic research, membrane trafficking, and potential autophagy pathway, especially focus on tumor promotion, disease pathogenesis, and discuss the possible underlying mechanisms that are regulated by Rab23.
Highlights
Rab proteins belong to the Ras small GTPases superfamily
Rab proteins cycle between a cytosolic GDP-bound off-state and a membrane-associated GTP-bound on-state, which are orchestrated by three types of upstream regulators, namely, GDI (GDP dissociation inhibitor), guanine nucleotide exchange factor, and GTPase activating proteins
Neither Rab9A nor Rab23 are co-localized to nurtirent-deprived autophagosomes. Both Rab9A and Rab23 are dispensable for starvation-induced autophagosome formation [28]. These results indicate Rab23 is localized in forming autophagosomes, autophagosomes as well as to autolysosomes and vanish from GAS-containing autophagosome-like vacuoles (GcAVs) during the later stages of autophagy
Summary
Rab has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab is a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visceral, and cutaneous tumor. Rab may play joint roles in autophagosome formation during anti-infection process against Group A streptococcus. We give a brief review on the functions of Rab, summarize the involvement of Rab in genetic research, membrane trafficking, and potential autophagy pathway, especially focus on tumor promotion, disease pathogenesis, and discuss the possible underlying mechanisms that are regulated by Rab. Accepted Manuscript Online: 19 January 2017 Version of Record published: 2 March 2017
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