Abstract
R1 reticulin antibodies were found in sera from patients with childhood celiac disease (CCD). Although the overall sensitivity of R1 in the diagnosis of CCD was relatively low (16/43 = 37%), when only those cases in an active phase of the disease were considered, the sensitivity increased (16/24 = 67%), In spite of its low sensitivity, the R1 assay did show a high degree of specificity, as this antibody was not found in children with post‐enteritis syndrome or in healthy controls. R1 antibodies, when found in active CCD, always turned out to be positive when tested on human liver as substrate. While this fact did not enhance the sensitivity of the test, it strengthened its specificity, since R1 found in pathological conditions other than CCD, was nearly always negative on human tissue. Although the R1 reticulin antibody test cannot replace jejunal biopsy in the diagnosis of CCD, its assay, particularly on human liver as substrate, can be considered a useful tool in the screening of celiac patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Pediatric Gastroenterology and Nutrition
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
