(R)-TRIP and (S)-TRIP – Very Recent Applications

Abstract

(R)- and (S)-3,3′-bis(2,4,6-triisopropylphenyl)-1,1′-binaphthyl-2,2′-diylhydrogenphosphates, also known as (R)-TRIP and (S)-TRIP are chiral phosphoric acids (CPA’s) derived from BINOL. They are available from commercial sources, and they can be prepared through a three-step sequence that starts with a Kumada coupling between compound 1 and two equivalents of 2,4,6-(triisopropoxy)phenylmagnesiumchloride. This reaction is followed by a deprotection and a high-yielding phosphorylation step (Scheme [1a]).[1]