Abstract
Background: There have been various studies related to fracture healing. Glutamine is an amino acid with an important role in many cell and organ functions. This study aimed to make a clinical, radiological, and histopathological evaluation of the effects of glutamine on fracture healing. Methods: Twenty rabbitswere randomly allocated into twogroups of control and immunonutrition. A fracture of the fibulawas made to the right hind leg. All rabbits received standard food and water. From post-operative firstdayfor30days,thestudygroupreceivedanadditional2ml/kg/day20% L-alanine L-glutaminesolutionviaa gastric catheter, and the control group received 2 ml/kg/day isotonic via gastric catheter. At the end of 30 days, the rabbits were sacrificed and the fractureswere examined clinically, radiologically, and histopathologically in respect to the degree of union. Results: Radiological evaluation of the control group determined a mean score of 2.5 according to the orthopaedists and 2.65 according to the radiologists. In the clinical evaluation, the mean score was 1.875 for the control group and 2.0 for the study group. Histopathological evaluation determined a mean score of 8.5 for the control group and 9.0 for the study group. Conclusion: One month afterorally administered glutaminealanine, positive effectswere observed on fracture healing radiologically, clinically, and histopathologically, although no statistically significant difference was determined.
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