Abstract
Quorum sensing (QS) is intracellular communication among bacteria that perceive population density, regulates the formation of biofilm, virulence factors production and provides resistance to antibiotics through extracellular signal molecules. Vibrio harveyi, a marine pathogen, and major cause for loss of productivity in aquaculture hatcheries, farms and for the growth of industry. V. harveyi uses multi-channel quorum sensing system, each consisting of an autoinducer-sensor pair that controls the expression of genes required for bioluminescence, virulence, biofilm formation. The multi-channel system is mediated by the V. harveyi autoinducer 1 (HAI-1), autoinducer 2 (AI-2), V. cholerae autoinducer 1 (CAI-1) which activate or inactivate target gene expressions by a phosphorylation/dephosphorylation signal transduction cascade. The production of extracellular virulence factors are involved in regulation of virulence and pathogenesis of V. harveyi. This article focuses on chemical communication mechanism, its regulation of virulence factors and pathogenicity of Vibrio harveyi.
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