Abstract
Vibrio campbellii utilizes the type III secretion system (T3SS) as a mechanism of pathogenesis, which is a highly studied 'injectisome' complex that delivers exotoxins into host cells during infection. The T3SS pathogenicity island in V. campbellii comprises ∼40 genes that are organized into four structural operons. In this study, we determined that quorum sensing - a method of bacterial communication - regulates T3SS genes both at the transcriptional and post-translational levels to shut down T3SS gene expression at high population densities.
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