Year-end Sale % OFF 
Abstract
Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70 years. It has been shown that morbidity increases with social graying. Quisqualis indica linn (QI) has been used to treat inflammation, stomach pain, and digestion problems. In this study, we evaluated the symptom-regulating effects of QI extract on a testosterone-induced BPH rat model. After inducing BPH in rats using testosterone propionate (TP) injection, we assessed basal intraurethral pressure (IUP) and increments of IUP elicited by electrical field stimulation (5 V, 5, 10, or 20 Hz) or phenylephrine (Phe) (0.01, 0.03, 0.1 mg/kg IV). To induce BPH, 8-week-old rats were subjected to a daily subcutaneous TP (3 mg/kg) injection for 4 weeks. Finasteride (Fina) (10 mg/kg PO) was administered to the rats in the first treatment, while QI (150 mg/kg PO) was administered to those in the second group. Blood pressure was measured together with IUP, after which low urinary tract (LUT), ventral prostate (VP), testicle, and corpus spongiosum were isolated and weighed. Basal IUPs for the Fina- and QI-treated groups were 87.6 and 86.8%, respectively.LUT and VP organ weights in the QI group were lower than those in the Fina group. However, the QI group showed significantly reduced electrical stimulated or Phe-induced IUP increment compared to the Fina and BPH groups. These results proved that QI can be beneficial for BPH symptoms by inhibiting 5α-reductase and consequently decreasing prostate and releasing urinary pressure.
Highlights
Benign Prostate Hyperplasia (BPH) is a common disease in old-age males that accounts for 77% of morbidity within the age range of 40 to 70 years [1]
Treatment effects of intraurethral pressure (IUP) baseline changes The effect of BPH induction and Quisqualis indica linn (QI) administration on baseline IUP was measured (Fig. 1)
IUP was 36.45 ± 1.30 mmHg in the BPH-induced group treated with QI, which was similar to the Fina group
Summary
Benign Prostate Hyperplasia (BPH) is a common disease in old-age males that accounts for 77% of morbidity within the age range of 40 to 70 years [1]. Men with BPH can experience great discomfort with urination due to urethral obstruction and irritation of the bladder. Obstructive symptoms include decreased voiding power, intermittent urine and delayed urination. Bladder irritation symptoms include frequent urination and nocturnal urination [3]. The pathogenesis of BPH is not fully understood, dihydrotestosterone (DHT) produced by the enzyme 5α-reductase, is known as the main mediator of prostatic stromal and epithelial hyperplasia. Enhanced smooth muscle tone in the urethra, prostate, and bladder neck is the main contributor to voiding symptoms. Changes in hormones, including the male hormone, and aging are factors responsible for the enlargement of the prostate gland [4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
