Abstract
Quinoxaline 1,4-di-N-oxides (QdNO’s) are potent drugs used since the middle of the last century as food additives to improve animal growth; however, their use as antibacterial agents led to an interest in investigating their mechanism of action, discovering that this heterocycle can cause DNA damage. Consequently, many molecules with different applications have been developed, with most of the research focused on studying their action as antibiotics, antifungals, antiparasitics, antituberculous, and anticancer agents. This review aims to present a condensate of the leading QdNO’s derivatives, as well as a description of the biological activities finding the importance of the nature and type of substituents present in positions R2, R3, R6, and R7 when they are biologically evaluated.
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