Abstract
Pathogens that carry antibacterial resistant genes represent a threat for failure of antibiotic therapy and are associated with high mortality, morbidity and expenses. In Bangladesh, although quinolone resistance in clinical infections has been reported, environmental influence to this resistance is poorly known. Thus, to examine the existence of quinolone resistant bacterial strains in surface water in Dhaka, the study was conducted during June 2012 to January 2014. Surface water samples from Dhaka city were screened and isolated quinolone resistant Pseudomonas putida, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Molecular and genetic analysis identified the resistant determinants in these isolates. The study suggests that potential role of water for the dissemination and transmission of resistant genes among microorganisms causing human and animal infections in Bangladesh.
Highlights
Quinolone is one of the most commonly prescribed broad spectrum antimicrobial in the world at present era
A total of 46 individual colonies were isolated from four water sample-cultures, where 10 (21.7%) isolates showed Minimum Inhibitory Concentrations (MICs) >4 for CIP
These bacteria were isolated from water collected from location no. 3 and 4
Summary
Quinolone is one of the most commonly prescribed broad spectrum antimicrobial in the world at present era. This class of drug is currently used to treat a number of diseases including pyelonephritis, sexually transmitted diseases, prostatitis, chronic bronchitis, community-acquired and nosocomial pneumonia, intra-abdominal, pelvic, skin and tissue infections.[1] But the increasing occurrence of microbial resistance to this drug is threatening confident use of quinolone in clinical infections. The objective of the study was to examine the existence of quinolone resistant bacterial strains in surface water in Dhaka. The study determined the molecular characteristics of these isolates
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