Abstract
The reaction of the quinoxaline N-oxide (8a) with diethyl ethoxymethylenemalonate gave the 1,4-dihydropyridazino[3,4-b]quinoxaline-4,4-dicarboxylate (10c), whose reaction with a base afforded the 1,5-di-hydropyridazino[3,4-b]quinoxaline-4-carboxylate (6a). The oxidation of compound (6a) with nitrous acid provided the 1,4-dihydro-4-hydroxypyridazino[3,4-b]quinoxaline-4-carboxylate (7), whose reaction with potassium hydroxide gave 7-chloro-1-methylpyridazino[3,4-b]quinoxalin-4(1H)-one (5a). On the other hand, the reaction of the quinoxaline N-oxide (8b) with acetylacctaldehyde dimethyl acetal afforded 4-acetyl-1,5-dihydro-1-methylpyridazino[3,4-b]quinoxaline (6b), whose oxidation with selenium dioxide provided 1-methylpyridazino[3,4-b]quinoxalin-4(1H)-one (5b).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
