Abstract
The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions. In order to overcome the aforementioned factors, several researchers have reported hybrid compounds prepared by reacting quinoline-based compounds with other compounds via selected functionalities. This review will focus on the currently reported quinoline-based hybrid compounds and their preclinical studies.
Highlights
Malaria is a parasitic infectious disease that is a threat to approximately half of the world’s population
Replacement with primaquine cancelled the blood-stage activity of the compounds. These findings revealed the role of the 4-amino-7-chloroquinoline ring system in the dual-stage antimalarial activity [56]
Raj et al prepared a class of quinoline-β-lactam hybrid compounds 34 in which the antimalarial activity was influenced by the linker, N-1 substituent of the β-lactam ring and the alkyl chain length
Summary
Malaria is a parasitic infectious disease that is a threat to approximately half of the world’s population. This parasitic disease is transmitted to humans by a female Anopheles mosquito when it takes a blood meal. Different approaches which include combination therapy have been evaluated. More than a decade ago, the combination therapy which involves the combination of two or more antimalarials has been reported to be the future approach to overcome drug resistance of antimalarials. Antimalarial drugs containing 4-aminoquinoline scaffolds are good precursors for hybridization with other antimalarials and metal-based compounds via selected functionalities [8]. This review will be focused on the synthesis, in vitro and in vivo studies of hybrid compounds containing 4- and 8-aminoquinoline derivatives
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