Quinoline‐fused both non‐peripheral and peripheral ZnIIand MgIIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Abstract

Quinoline‐fused ZnII(ZnPcp/ZnPcnp) and MgII(MgPcp/MgPcnp) phthalocyanines with four 4‐methylquinolin‐2‐ol (1) at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non‐peripheral ZnIIand MgIIphthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α‐glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.