Abstract
Quinine dosage and peritoneal clearance of urea, creatinine, and quinine were studied in four patients undergoing treatment for acute renal failure complicating chloroquine-resistant Plasmodium falciparum malaria with blackwater fever (malarial hæmoglobinuria). Quinine dihydrochloride was administered by constant intravenous infusion to each patient. Peritoneal dialysis was effective in treating the acute renal failure component of the disease process. The clearance of urea and creatinine across the peritoneal membrane was reduced during the early phase of malaria, but increased as the patients' malaria improved clinically. The total concentrations of quinine removed by dialysis were trivial, and this procedure did not alter the markedly elevated plasma quinine levels observed during the first 48-72 hours of intravenous quinine infusion. To avoid quinine toxicity and potential fatalities, reduced dosage (600 mg. per 24 hours) should be used until the patient is in the recovery phase of renal failure and malaria.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
