Abstract
BackgroundDengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk.ResultsWith the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.ConclusionsTaken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-015-0443-9) contains supplementary material, which is available to authorized users.
Highlights
Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world
Cytotoxicity of quinic acid derivatives Both quinic acid (Table 1) and several of its derivatives have been shown to protect human lymphocytes from damage induced by X-ray [22] and from cell death induced by tetrahydropapaverolin [23]
It has been demonstrated that the amides of quinic acid derivatives exhibited anti-inflammatory activities both in vitro and in vivo and they may serve as attractive options for therapeutic use [24, 25]
Summary
Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk. Among all human arthropod-borne viral diseases, dengue is the most prevalent, representing a health threat in tropical and sub-tropical areas of the world [1, 2]. There are approximately 2.5 billion people living in endemic areas, and 390 million dengue cases are estimated per year including 25,000 dengue-related deaths [1, 3].
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