Abstract
AbstractControlling phytopathogenic diseases caused by oomycete fungi is still a challenge in crop protection research. Studies on identifying new starting points to control phytopathogens revealed that the quinazolinone alkaloids febrifugine (1) and halofuginone (2) are efficiently inhibiting the growth of Phytophthora infestans in microtiter tests. However, despite the very good in vitro activity of 0.13 and 0.06 ppm in IC50, respectively, both compounds did not exhibit a good control of P. infestans on tomato plants. Creating a homology model of prolyl‐tRNA synthetase – the molecular target of halofuginone – helped to understand the interactions between 2 and the binding pocket and guided the synthesis of further derivatives. Ultimately, we found that deoxy‐febrifugine (14) and halofuginol (17) and its derivatives were able to control P. infestans also on the plant.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
