Abstract
Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
Highlights
The fungus Aspergillus fumigatus is known as an important human pathogen, which produces many secondary metabolites
Hong et al re-identified the fungus Aspergillus novofumigatus CBS11520 as the new Aspergillus sp., which is closely related to A. fumigatus [1]
We have previously reported the isolation of two diketopiperazines, novoamauromine and ent-cycloechinulin, and a cyclic tripeptide, novofumigatamide, from the MeOH extract of this fungus cultivated on rice [2, 3]
Summary
The fungus Aspergillus fumigatus is known as an important human pathogen, which produces many secondary metabolites. Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus 939 Analysis of the 1H 1H COSY and HMBC spectra supported the planar structure of 2 being the 20-hydroxy derivative of 1 (Figure 2). Effect of novobenzomalvins on expression of fibronectin in NHDF-neo cells.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
