Abstract
SINCE the possibilities of revealing chromosomal structure by staining chromatin with dyes derived from acridine first became apparent1, we have used the antimalarial compound quinacrine dihydrochloride (‘Atebrin’, G. Gurr Ltd) to study the highly fluorescent area on the long arms of the human Y chromosome and in localized regions of certain autosomes2–4. We now describe an investigation of the chromosomes of various mammals, including man, to see whether quinacrine fluorescence is a universal property of all mammalian Y chromosomes or a reaction specific to man. We find that fluorescence of the intensity found on the human Y chromosome is only present in the African great apes and man.
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