Quiescent trophoblastic disease and minimally aggressive gestational trophoblastic neoplasm

Abstract

The presence and absence of invasive or malignant choriocarcinoma or gestational trophoblastic neoplasm (GTN) can be shown by the presence and absence of serum hyperglycosylated hCG. If a patient has a history of choriocarcinoma, or hydatidiform mole, and suddenly has no detectable hyperglycosylated hCG (<5% of total hCG) with plateauing total hCG concentration, then that patient probably no longer has invasive or malignant disease. This is quiescent gestational trophoblastic disease or inactive disease. A high proportion of patients with gestational trophoblastic disease history, whether hydatidiform mole, invasive mole, choriocarcinoma, or GTN, will go through a period of plateauing total hCG levels (1.1–246 mIU/ml) and no detectable hyperglycosylated hCG.