Abstract
Quetiapine combined with sodium valproate is an effective and more suitable drug treatment for Alzheimer's disease. At present, there are relatively few studies on the combined action mechanism of these two drugs. This study has certain practical value. Alzheimer's disease is a multifaceted, highly genetically heterogeneous neurodegenerative disease. The main clinical manifestations are memory loss, abnormal mental behavior, and loss of various cognitive functions. In order to improve the symptoms of patients with Alzheimer's disease, especially those with mental symptoms, this article combines quetiapine and sodium valproate, two commonly used drugs for the treatment of mental illnesses, and applies them to different levels of Alzheimer's and observes the results of the combination's curative effect. This article introduces Alzheimer's disease and its potential mental behaviors in the method section, and it also introduces the mechanism of action of quetiapine and sodium valproate. For the algorithm, this paper introduces a data mining algorithm to understand the effect of drug efficacy. In the experimental part, firstly, it introduces the experimental objects, the proportion of medicines, and the statistical methods. Secondly, this article covers adverse reactions, inflammatory factors and vascular endothelial indicators, Alzheimer's disease performance, MOAS score, treatment effect evaluation, and satisfaction surveys. It can be seen from the experiment that, in mental behavior, the experimental group decreased from 8.2 before treatment to 0.5, and the control group decreased from 7.1 before treatment to 2.6. It can be seen that the scores of the experimental group changed after receiving the treatment of quetiapine combined with sodium valproate.
Highlights
Dementia refers to acquired and persistent cognitive impairment syndromes caused by brain dysfunction
Sodium valproate is a broadspectrum antiepileptic drug. It is an inhibitor of GABA transaminase in the brain, which can slow down the catabolism of GABA; at the same time, it can increase the activity of glutamate decarboxylase and increase the production of GABA, thereby increasing the GABA content of inhibitory synapses in the brain, and can increase postsynaptic inhibition. e membrane is responsive to GABA, thereby enhancing GABAergic postsynaptic inhibition
Many studies have shown that quetiapine has a positive effect on the positive and negative symptoms of schizophrenia, which can improve the cognitive function of patients, thereby improving the social adaptability and individual psychology of patients, which can be seen to promote physical and mental recovery [20, 21]
Summary
Dementia refers to acquired and persistent cognitive impairment syndromes caused by brain dysfunction. Based on the two drugs of quetiapine and sodium valproate, this article observes and studies the therapeutic effects of patients with Alzheimer’s disease with psychobehavioral symptoms. E innovation of this article is that it combines quetiapine and sodium valproate, two drugs for the treatment of mental illness, and analyzes a variety of scoring indicators related to Alzheimer’s disease. 2. Curative Effect of Quetiapine Combined with Sodium Valproate on Patients with Alzheimer’s Disease Accompanied by Mental and Behavioral Symptoms Observation Method. Many studies have shown that quetiapine has a positive effect on the positive and negative symptoms of schizophrenia, which can improve the cognitive function of patients, thereby improving the social adaptability and individual psychology of patients, which can be seen to promote physical and mental recovery [20, 21]. Children and adolescents do not have precise regulations on the dosage of this drug, and this drug has not been formally approved. e side effects caused by it are too large, and the physique of children and adolescents is relatively weak
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