Abstract

The classification of TST results is based on epidemiologic and clinical factors. The size of induration (mm) for a positive result varies with the person's risks of latent tuberculosis infection and progression to tuberculosis disease. Current guidelines from the Centers for Disease Control, American Thoracic Society, and American Academy of Pediatrics accept 15 mm or greater as a positive TST result for any person. Induration of 5 mm to 15 mm may be interpreted as a positive reading in specific populations. A summary of these is presented the 2003 Redbook. Treatment for any positive TST includes a radiograph of the chest and a drug regimen for 6-9 months. Isoniazid once daily for 9 months; rifampin once daily for 6 months; or a 2-month course of isoniazid, rifampin, and pyrazinamide daily followed by 4 months of isoniazid and rifampin are the usual treatment choices. A tuberculosis specialist should be consulted for any resistant infection and when close observation is necessary.

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