Abstract
Absorption of quercetin, a flavonoid regarded as a beneficial dietary factor, was studied in rats. The compound was administered orally in propylene glycol, water/propylene glycol, and water. Quercetin's solubility in vehicles used for quercetin administration was measured. Following administration, tail vein blood was collected as a function of time. Concentrations of quercetin and its metabolites in rat blood plasma were measured by HPLC with electrochemical detection after hydrolysis of respective conjugates with β-glucuronidase and/or sulfatase. Pharmacokinetic profiles of quercetin and isorhamnetin, its 3‘-methoxy derivative, were obtained, and on their basis it was concluded that isorhamnetin was present in rat blood plasma mainly as sulfate/glucuronide conjugates. Quercetin's solubility in solvents used for its administration was compared with respective absorption profiles. This comparison revealed that solubilization enhanced quercetin absorption; however, its lack was not an absorption-limiting ...
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