Abstract
Absorption of quercetin, a flavonoid regarded as a beneficial dietary factor, was studied in rats. The compound was administered orally in propylene glycol, water/propylene glycol, and water. Quercetin's solubility in vehicles used for quercetin administration was measured. Following administration, tail vein blood was collected as a function of time. Concentrations of quercetin and its metabolites in rat blood plasma were measured by HPLC with electrochemical detection after hydrolysis of respective conjugates with β-glucuronidase and/or sulfatase. Pharmacokinetic profiles of quercetin and isorhamnetin, its 3‘-methoxy derivative, were obtained, and on their basis it was concluded that isorhamnetin was present in rat blood plasma mainly as sulfate/glucuronide conjugates. Quercetin's solubility in solvents used for its administration was compared with respective absorption profiles. This comparison revealed that solubilization enhanced quercetin absorption; however, its lack was not an absorption-limiting ...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.