Quercetin Supplementation Improves Neuromuscular Function Recovery from Muscle Damage.

Ilenia Bazzucchi,Roberta Ceci,Paolo Sgrò,Federica Patrizio,Stefania Sabatini,Massimo Sacchetti,Guglielmo Duranti,Luigi Di Luigi

doi:10.3390/nu12092850

Ilenia Bazzucchi, Roberta Ceci + Show 6 more

Open Access

https://doi.org/10.3390/nu12092850

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Journal: Nutrients	Publication Date: Sep 17, 2020
Citations: 16	License type: CC BY 4.0

Affiliation: Foro Italico University of Rome

Abstract

This study was aimed at investigating whether quercetin (Q) may improve the recovery of neuromuscular function and biochemical parameters in the 7 days following an eccentric exercise-induced muscle damage (EEIMD). Sixteen men (25.9 ± 3.3 y) ingested Q (1000 mg/day) or placebo (PLA) for 14 days following a double-blind crossover study design. A neuromuscular (NM) test was performed pre–post, 24 h, 48 h, 72 h, 96 h and 7 days after an intense eccentric exercise. The force–velocity relationship of the elbow flexor muscles and their maximal voluntary isometric contraction (MVIC) were recorded simultaneously to the electromyographic signals (EMG). Pain, joint angle, arm circumference, plasma creatine kinase (CK) and lactate-dehydrogenase (LDH) were also assessed. The results showed that Q supplementation significantly attenuated the strength loss compared to PLA. During the recovery, force–velocity relationship and mean fibers conduction velocity (MFCV) persisted significantly less when participants consumed PLA rather than Q, especially at the highest angular velocities (p < 0.02). A greater increase in biomarkers of damage was also evident in PLA with respect to Q. Q supplementation for 14 days seems able to ameliorate the recovery of eccentric exercise-induced weakness, neuromuscular function impairment and biochemical parameters increase probably due to its strong anti-inflammatory and antioxidant action.

Highlights

During eccentric exercise, skeletal muscle is exposed to stretch and overload which causes structural damage to myofibers and secondary inflammation resulting from leukocyte infiltration into the damaged tissues [1]
What is still unclear is whether this protective action can reduce the extent of muscle damage but whether it can improve the recovery from the damage itself
This study has shown that 14-day Q supplementation attenuates the magnitude of time was found but when volunteers consumed PLA and the mean values referred by the participants damage resulting from eccentric exercise, and ameliorates the time course of symptoms after the eccentric protocol (POST) were significantly higher than BASELINE (p = 0.017)

Summary

Introduction

Skeletal muscle is exposed to stretch and overload which causes structural damage to myofibers and secondary inflammation resulting from leukocyte infiltration into the damaged tissues [1]. Signs and symptoms of eccentric exercise-induced muscle damage (EEIMD) often persist for several days after conclusion of exercise and typically include muscle pain, localized swelling, temporary decrements in maximal force-generating capacity, altered joint kinematics, elevated levels of intramuscular enzymes (i.e., creatine kinase (CK) and lactate dehydrogenase (LDH)), elevations in markers of inflammation and various interleukins [2,3]. Q supplementation, has been shown to reduce the entity of strength loss caused by action potential propagation impairment and myofibrillar disruption which characterized an eccentric exercise-induced muscle damage. What is still unclear is whether this protective action can reduce the extent of muscle damage but whether it can improve the recovery from the damage itself

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