Quercetin Prevents Bisphenol S Induced Behavioral Changes and Oxidative Stress iZebrafish by Modulating Brain Antioxidant Defense Mechanism

Abstract

ABSTRACT: The man-made xenoestrogen bisphenol S has been well-established and associated with developing neoplasm, dementia, neurotoxicity, anxiety, and other adverse effects in people and other organisms. The mechanisms of BPS-induced toxicity have been studied; however, it is unclear if there is any prospect for improvement by natural means. After being exposed to BPS through water, zebrafish (Danio rerio) were employed in this investigation to determine whether quercetin co-supplementation could lessen the compound's destructive potential. Laboratory tests were done to see if quercetin's antioxidant properties may shield the zebrafish brain from oxidative stress and altered behavioral responses brought on by BPS. The available evidence shows that quercetin is beneficial in reducing the abnormal behavioral response brought on by BPS. Quercetin (QU) may have therapeutic potential for reducing oxidative stress caused by BPS, according to biochemical research conducted in the zebrafish brain. In addition, quercetin guards the zebrafish brain against toxicity brought on by BPS. These preliminary findings imply that quercetin, which reduces the generation of reactive oxygen species, would be an effective treatment for BPS-induced toxicity in zebrafish.